Co-57-based intercomparison of TLC scanners and dose calibrators for low-activity radiochemical purity assessment in radiopharmaceutical quality control

Regular participation in intercomparison campaigns is essential for harmonizing practices and ensuring reproducible, reliable results. Thin layer chromatography results can be affected by scanner settings, procedural variations, and subjective peak integration. By comparing thin layer chromatography scanners and dose calibrators, we identified potential instrument biases and methodological discrepancies when values were out of tolerance. Our intercomparison contributed to improving the performance and comparability of radiochemical purity measurements across Swiss nuclear medicine institutions.