PD-1 blockade does not enhance alloimmunization after allogeneic dendritic cell vaccination in cancer patients

These results indicate that, during allogeneic human vaccination, PD-1 signaling exerts a limited effect on antibody production and effector function, suggesting a more complex regulatory role in humoral immunity than previously thought.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-03-04
DOI
https://doi.org/10.3389/fimmu.2026.1763434
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.00
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article

PD-1 blockade does not enhance alloimmunization after allogeneic dendritic cell vaccination in cancer patients

C. Van De Kerkhove, P. Saas, Friederike C. Althoff, Elvire Pons‐Tostivint et al.
Frontiers in Immunology
Cancer Immunotherapy and Biomarkers
article

PD-1 blockade does not enhance alloimmunization after allogeneic dendritic cell vaccination in cancer patients

C. Van De Kerkhove, P. Saas, Friederike C. Althoff, Elvire Pons‐Tostivint, Françoise Myster, Ingel Demedts, F. Cantero, L. Chaperot, Estelle Leplus, F. Borm, Marcin Skrzypski, Karine Laulagnier, Gianni Maggipinto, Florence Renard, Anne Sibille, Séverine Planel, B. Colinet, B. Biesma, Guillaume Vayssière, Willemijn S. M. E. Theelen, Els Wauters, Kristof CUPPENS, Eva Buchmeier, Marie Gerard, Joël Plumas, Maurice Pérol, Johan Vansteenkiste, Denis Moro-Sibilot
article en

Abstract

These results indicate that, during allogeneic human vaccination, PD-1 signaling exerts a limited effect on antibody production and effector function, suggesting a more complex regulatory role in humoral immunity than previously thought.

Frontiers in ImmunologyVol. 17
Goethe University Frankfurt (DE), Centre National de la Recherche Scientifique (FR), Goethe-Institute United Kingdom (GB), Inserm (FR), Dr. M.G.R. Educational and Research Institute (IN), Leiden University Medical Center (NL), AZ Groeninge (BE), Centre Hospitalier Universitaire de Grenoble (FR), Jessa Hospital (BE), UCB Pharma (France) (FR), Centre Léon Bérard (FR), Oncode Institute (NL), Vlaamse Vereniging voor Obstetrie en Gynaecolo (BE), Kliniken der Stadt Köln (DE), Établissement Français du Sang (FR), Centre Hospitalier Universitaire de Liège (BE), AZ Delta (BE), Grand Charleroi Hospital (BE), Jeroen Bosch Ziekenhuis (NL), Institut pour l'avancée des biosciences (FR), Gdańsk Medical University (PL), UCB Pharma (Belgium) (BE), Université Grenoble Alpes (FR), Nantes Université (FR), KU Leuven (BE)
Good health and well-being
Openalex Percentile: Top 34%
Cancer Immunotherapy and Biomarkers
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