PD-1 blockade does not enhance alloimmunization after allogeneic dendritic cell vaccination in cancer patients
These results indicate that, during allogeneic human vaccination, PD-1 signaling exerts a limited effect on antibody production and effector function, suggesting a more complex regulatory role in humoral immunity than previously thought.
Authors
- C. Van De Kerkhove
- P. Saas
- Friederike C. Althoff (ORCID: https://orcid.org/0000-0003-0702-5334)
- Elvire Pons‐Tostivint (ORCID: https://orcid.org/0000-0003-4478-0523)
- Françoise Myster (ORCID: https://orcid.org/0009-0000-7147-480X)
- Ingel Demedts (ORCID: https://orcid.org/0000-0002-2949-8821)
- F. Cantero
- L. Chaperot
- Estelle Leplus
- F. Borm
- Marcin Skrzypski (ORCID: https://orcid.org/0000-0002-4391-4318)
- Karine Laulagnier (ORCID: https://orcid.org/0000-0001-6115-9128)
- Gianni Maggipinto (ORCID: https://orcid.org/0000-0002-5448-8625)
- Florence Renard
- Anne Sibille
- Séverine Planel
- B. Colinet
- B. Biesma
- Guillaume Vayssière
- Willemijn S. M. E. Theelen
- Els Wauters
- Kristof CUPPENS
- Eva Buchmeier
- Marie Gerard
- Joël Plumas
- Maurice Pérol
- Johan Vansteenkiste
- Denis Moro-Sibilot
Institutions
- Goethe University Frankfurt (DE)
- Centre National de la Recherche Scientifique (FR)
- Goethe-Institute United Kingdom (GB)
- Inserm (FR)
- Dr. M.G.R. Educational and Research Institute (IN)
- Leiden University Medical Center (NL)
- AZ Groeninge (BE)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Jessa Hospital (BE)
- UCB Pharma (France) (FR)
- Centre Léon Bérard (FR)
- Oncode Institute (NL)
- Vlaamse Vereniging voor Obstetrie en Gynaecolo (BE)
- Kliniken der Stadt Köln (DE)
- Établissement Français du Sang (FR)
- Centre Hospitalier Universitaire de Liège (BE)
- AZ Delta (BE)
- Grand Charleroi Hospital (BE)
- Jeroen Bosch Ziekenhuis (NL)
- Institut pour l'avancée des biosciences (FR)
- Gdańsk Medical University (PL)
- UCB Pharma (Belgium) (BE)
- Université Grenoble Alpes (FR)
- Nantes Université (FR)
- KU Leuven (BE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fimmu.2026.1763434
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00