Cardioprotective Effects of Finerenone Associated With the Suppression of Myocardial Sodium Accumulation in Aldosterone/Salt‐Loaded Rats
These findings suggest that finerenone inhibits cardiac dysfunction induced by aldosterone/salt through the suppression of sodium accumulation in left ventricular tissues and attenuate subsequent macrophage-mediated inflammation, thereby preventing adverse cardiac remodeling and dysfunction.
Authors
- Yoshio Konishi (ORCID: https://orcid.org/0009-0006-2029-8977)
- Nourin Jahan
- Hiroyuki Ohsaki
- Yoshihide Fujisawa
- Takashi Morikawa (ORCID: https://orcid.org/0000-0003-4445-9270)
- Akira Nishiyama (ORCID: https://orcid.org/0000-0002-8802-3770)
- Daisuke Yamazaki (ORCID: https://orcid.org/0000-0003-4981-3056)
- MD ENAYET KABIR
- Md. Moshiur Rahman
- Takeshi Imamura
- Keiko Yamakawa
- Juanjuan Ye
- Asadur Rahman
- Tatsuya Sawano
- Kento Kitada
- Kyuichi Kadota
Institutions
- Hyogo University of Health Sciences (JP)
- Kagawa University (JP)
- Osaka City General Hospital (JP)
- Juntendo University Hospital (JP)
- Tottori University (JP)
- Kobe University (JP)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1161/jaha.125.044798
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00