A STING signaling relay from tumor cells to macrophages mediates the improved efficacy of combination chemotherapy in pancreatic cancer
This study reports AGP regimen as a promising therapeutic modality for PDAC, and provides a detailed mechanism by which a STING-mediated signaling relay from PDAC tumor cells to TAMs boost antitumor immunity and contribute to AGP chemotherapy efficacy. Furthermore, STING expression in tumor tissues correlated with improved prognosis, highlighting its potential as a predictive biomarker and promising therapeutic target.
Authors
- Jinheng Wang (ORCID: https://orcid.org/0000-0002-2650-3816)
- Xiaojun Xia (ORCID: https://orcid.org/0000-0002-4488-8406)
- Qiuxia Yang (ORCID: https://orcid.org/0009-0004-1263-8770)
- Yize Mao
- Shengping Li
- Kaili Xing
- Hui Guo
- Ruiqi Wang
- Jing Xue
- Honglu Ding
- Zining Wang
- Jun Wang (5906)
- Zehui Yao
- Xiaojuan Wang
- Yongxiang Liu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Renji Hospital (CN)
- Guangzhou University (CN)
- Guangzhou Experimental Station (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- Shanghai Cancer Institute (CN)
- State Key Laboratory of Oncogene and Related Genes (CN)
- Sun Yat-sen University Cancer Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Hainan Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1186/s12929-026-01226-1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00