Cognitive dysfunction and hippocampal metabolic alterations in patients with postherpetic neuralgia

PHN patients have a high incidence of cognitive impairment, mainly characterized by reduced visualspatial execution, attention and abstraction abilities, they also exhibit metabolic changes in bilateral hippocampus. Among them, PHN patients with long duration of disease and severe pain have more significant changes. For the management of PHN patients, clinicians should not only pay attention to the patient's pain symptoms, but also to their cognitive and emotional disorders.