Complement C9 deficiency as a novel risk factor for invasive Candida esophagitis in children: a single case in-depth analysis

Isolated C9 deficiency may represent a susceptibility factor for recurrent fungal esophagitis with stricture formation in children. Complement screening should be considered in unexplained recurrent cases. Combined antifungal therapy and endoscopic intervention achieved sustained remission in this patient.

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Publication Details

Journal
BMC Pediatrics
Published
2026-03-04
DOI
https://doi.org/10.1186/s12887-026-06681-1
Primary Topic
Complement system in diseases
Type
article
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article

Complement C9 deficiency as a novel risk factor for invasive Candida esophagitis in children: a single case in-depth analysis

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Complement system in diseases
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Complement C9 deficiency as a novel risk factor for invasive Candida esophagitis in children: a single case in-depth analysis

Yinshuo Wang, Zheng Tan, Kerong Peng, Guimei Zheng, Weizhong Gu, Jian J. Zhang, Lanfang Tang
article en

Abstract

Isolated C9 deficiency may represent a susceptibility factor for recurrent fungal esophagitis with stricture formation in children. Complement screening should be considered in unexplained recurrent cases. Combined antifungal therapy and endoscopic intervention achieved sustained remission in this patient.

BMC Pediatrics
Children's Hospital of Zhejiang University (CN), Hangzhou Children's Hospital (CN)
Zero hunger
Openalex Percentile: Top 35%
Complement system in diseases
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