Lycium L. flavonoids: extraction, purification, signal transduction pathways, and interactions with intestinal microbiota

Flavonoids are major bioactive constituents of Lycium L. with diverse pharmacological activities. This review summarizes recent advances in the extraction, characterization, and biological functions of Lycium flavonoids (LyFs). Evidence indicates that LyFs exert antioxidant, anti-inflammatory, and immunomodulatory effects via pathways such as NF-κB and Keap1-Nrf2/ARE. Notably, LyFs act as functional prebiotics by modulating gut microbiota and short-chain fatty acid production, supporting intestinal and metabolic health.

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Publication Details

Journal
npj Science of Food
Published
2026-03-04
DOI
https://doi.org/10.1038/s41538-026-00784-w
Primary Topic
Polysaccharides and Plant Cell Walls
Type
article
Field-Weighted Citation Impact
0.00
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article

Lycium L. flavonoids: extraction, purification, signal transduction pathways, and interactions with intestinal microbiota

Guozhen Duan, Yuxin Zhang, Youchao Qi, Tian Lan et al.
npj Science of Food
Polysaccharides and Plant Cell Walls
article

Lycium L. flavonoids: extraction, purification, signal transduction pathways, and interactions with intestinal microbiota

Guozhen Duan, Yuxin Zhang, Youchao Qi, Tian Lan, Guanghui Fan, Yonggui Ma, Kexin Zhou
article en

Abstract

Flavonoids are major bioactive constituents of Lycium L. with diverse pharmacological activities. This review summarizes recent advances in the extraction, characterization, and biological functions of Lycium flavonoids (LyFs). Evidence indicates that LyFs exert antioxidant, anti-inflammatory, and immunomodulatory effects via pathways such as NF-κB and Keap1-Nrf2/ARE. Notably, LyFs act as functional prebiotics by modulating gut microbiota and short-chain fatty acid production, supporting intestinal and metabolic health.

npj Science of Food
Qinghai University (CN), Qinghai Normal University (CN), Qinghai Tibetan Hospital (CN)
Openalex Percentile: Top 36%
Polysaccharides and Plant Cell Walls
DOIOpen Access PDFOpenAlex
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Lycium L. flavonoids: extraction, purification, signal transduction pathways, and interactions with intestinal microbiota — Guozhen Duan, Yuxin Zhang, et al. · npj Science of Food (2026) | TGRS Research Map | TGRS