Peroxisomal activity drives aggressive bladder cancer phenotypes and reveals erythorbic acid as a potential therapeutic modulator
Peroxisome-related gene dysregulation shapes the metabolic and immunologic heterogeneity of bladder cancer. Erythorbic acid emerges as a promising redox-metabolic modulator targeting multiple peroxisomal enzymes, offering a potential therapeutic avenue for aggressive, high-risk BLCA subtypes.
Authors
- Fei Wang (ORCID: https://orcid.org/0000-0001-6990-636X)
- Qinghui Wu (ORCID: https://orcid.org/0000-0002-9437-9036)
- Zhaocong Zheng (ORCID: https://orcid.org/0000-0002-4155-3774)
- Zhewen Ou
- Yu Zhou
- Daoyuan Li
- Housheng Fu
Institutions
- Guangzhou Medical University Cancer Hospital (CN)
- Hainan Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fonc.2026.1734437
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00