Spatial and cellular composition of lung fibrosis induced by multi-walled carbon nanotubes
These findings highlight the hazardous potential of inhaled MWCNTs based on macrophage superactivation induced by Slamf7 in the lung, providing mechanistic evidence for the lung-gut link described in traditional Chinese medicine. Together, our results identify molecular targets to mitigate nanomaterial immunotoxicity and inform the design and using of safer, surface-engineered MWCNTs.
Authors
- Biqi Han (ORCID: https://orcid.org/0000-0001-9780-4475)
- Jiayi Li (ORCID: https://orcid.org/0000-0001-6888-0380)
- Ying Liu
- Jingjing Lu (ORCID: https://orcid.org/0000-0001-8574-8824)
- Zhigang Zhang (ORCID: https://orcid.org/0000-0003-2380-1719)
- Shuke Ji
- Miaomiao Li
- Zhanjun Lv
- Xinwei Li
- Jiawen Tian
- Dongfang Liu
- Siyu Li
Institutions
- Inner Mongolia Agricultural University (CN)
- Northeast Agricultural University (CN)
- Jilin University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1186/s12951-026-04135-5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00