Adaptation métabolique des podocytes à l’exposition aux acides gras

A key feature of obesity-related chronic kidney disease (CKD) is the alteration of the glomerulus, known as obesity-related glomerulopathy (ORG). In this condition, podocytes, highly specialized glomerular epithelial cells, are the main target. Obesity-driven lipid accumulation may disrupt podocyte homeostasis by affecting its bioenergetics. We developed an in vitro model of podocyte lipid overload and found that fatty acids (FAs) partitioning varies according to the nature of the FA (saturated or not). This study provides a better insight into podocyte metabolism and how this cell adapts to lipid exposure.