Vitamin D inhibits the development of colorectal cancer cells by regulating the gut microbiota and immune microenvironment using JAKSTAT signaling pathway

Vitamin D inhibits excessive activation of the JAK-STAT pathway through VDR activation, ameliorates gut microbiota dysbiosis, restores butyrate metabolism, and rebalances macrophage polarization.

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Publication Details

Journal
Immunopharmacology and Immunotoxicology
Published
2026-03-03
DOI
https://doi.org/10.1080/08923973.2026.2630162
Primary Topic
Cytokine Signaling Pathways and Interactions
Type
article
Field-Weighted Citation Impact
0.00
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article

Vitamin D inhibits the development of colorectal cancer cells by regulating the gut microbiota and immune microenvironment using JAKSTAT signaling pathway

Geyan Bai, Min Fan, Yinglong Tao
Immunopharmacology and Immunotoxicology
Cytokine Signaling Pathways and Interactions
article

Vitamin D inhibits the development of colorectal cancer cells by regulating the gut microbiota and immune microenvironment using JAKSTAT signaling pathway

Geyan Bai, Min Fan, Yinglong Tao
article en

Abstract

Vitamin D inhibits excessive activation of the JAK-STAT pathway through VDR activation, ameliorates gut microbiota dysbiosis, restores butyrate metabolism, and rebalances macrophage polarization.

Immunopharmacology and Immunotoxicology
Xinjiang Medical University (CN), Tumor Hospital of Xinjiang Medical University (CN), People's Hospital of Xinjiang Uygur Autonomous Region (CN)
Good health and well-being
Openalex Percentile: Top 34%
Cytokine Signaling Pathways and Interactions
DOISourceOpenAlex
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