PPG-CAGAN: A PPG signal with coronary artery disease synthesis method based on generative adversarial learning

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Photoplethysmography (PPG) has become an important tool for cardiovascular disease monitoring due to its ease of measurement. However, studies on the CAD detection based on PPG signals face challenges such as data scarcity and class imbalance, which limit the accuracy and robustness of models. In this study, we propose a novel generative adversarial network called PPG-CAGAN for generating PPG signals. The model incorporates Bi-LSTM, Res-CBAM, and Parallel Multi-Scale Attention mechanism (PMSA) to improve the accuracy of PPG signal generation. Experimental results show that PPG-CAGAN achieves excellent performance on multiple evaluation metrics for generating PPG signals of different lengths. Compared to other data augmentation methods, PPG-CAGAN generates more realistic PPG signals, effectively enhancing the generalization ability of coronary artery disease detection models. Therefore, the data augmentation method proposed in this study effectively addresses the issues of PPG data scarcity and class imbalance for coronary artery disease, which is of great significance for improving the performance of the intelligent detection model of CAD based on PPG. • Novel PPG-CAGAN model for generating high-quality PPG signals. • Hybrid Bi-LSTM, Res-CBAM, and PMSA modules enhance the performance of the PPG generative model. • Effectively solves data scarcity and class imbalance in CAD detection.

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Publication Details

Journal
Biomedical Signal Processing and Control
Published
2026-03-03
DOI
https://doi.org/10.1016/j.bspc.2026.109964
Primary Topic
ECG Monitoring and Analysis
Type
article
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article

PPG-CAGAN: A PPG signal with coronary artery disease synthesis method based on generative adversarial learning

J D Liu, Weikun Zhou, Chunying Pang, Ye Li et al.
Biomedical Signal Processing and Control
ECG Monitoring and Analysis
article

PPG-CAGAN: A PPG signal with coronary artery disease synthesis method based on generative adversarial learning

J D Liu, Weikun Zhou, Chunying Pang, Ye Li, Xinlin Luo, Xiran Zhang, Jingyi Li
article en

Abstract

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Photoplethysmography (PPG) has become an important tool for cardiovascular disease monitoring due to its ease of measurement. However, studies on the CAD detection based on PPG signals face challenges such as data scarcity and class imbalance, which limit the accuracy and robustness of models. In this study, we propose a novel generative adversarial network called PPG-CAGAN for generating PPG signals. The model incorporates Bi-LSTM, Res-CBAM, and Parallel Multi-Scale Attention mechanism (PMSA) to improve the accuracy of PPG signal generation. Experimental results show that PPG-CAGAN achieves excellent performance on multiple evaluation metrics for generating PPG signals of different lengths. Compared to other data augmentation methods, PPG-CAGAN generates more realistic PPG signals, effectively enhancing the generalization ability of coronary artery disease detection models. Therefore, the data augmentation method proposed in this study effectively addresses the issues of PPG data scarcity and class imbalance for coronary artery disease, which is of great significance for improving the performance of the intelligent detection model of CAD based on PPG. • Novel PPG-CAGAN model for generating high-quality PPG signals. • Hybrid Bi-LSTM, Res-CBAM, and PMSA modules enhance the performance of the PPG generative model. • Effectively solves data scarcity and class imbalance in CAD detection.

Biomedical Signal Processing and ControlVol. 120
Changchun University of Science and Technology (CN), Jinan University (CN), Shenzhen Polytechnic University (CN), Chinese Academy of Sciences (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Shenzhen Institutes of Advanced Technology (CN), Fu Wai Hospital (CN)
Openalex Percentile: Top 41%
ECG Monitoring and Analysis
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