Antibody response induced by structural proteins from Triatoma virus as potential adjuvants in experimental immunisation models
Immunisation with <i>L. amazonensi</i>s antigens revealed that VPs preferentially induced IgG2b and IgG3 antibodies, whereas in experiments with <i>T. cruzi</i> antigens, IgG2b was predominant, accompanied by similar levels of IgG2a and IgG3, compared to lower IgG1 responses. These findings suggest that recombinant structural proteins of TrV-VLPs represent a promising adjuvant strategy capable of modulating humoral immune responses, offering potential applications in vaccine development against protozoan parasites such as Leishmania spp. and <i>T. cruzi</i>.
Authors
- Diego M. A. Guérin (ORCID: https://orcid.org/0000-0001-8504-9636)
- Alzira Regina Silva de Deus (ORCID: https://orcid.org/0000-0001-7594-3204)
- Aline Maria Vasconcelos Queiroz (ORCID: https://orcid.org/0000-0002-1811-7376)
- Paola Alejandra Fiorani Celedón (ORCID: https://orcid.org/0000-0002-1968-7039)
- Annamairlla do Nascimento Oliveira
- I. M. G. Santos (ORCID: https://orcid.org/0000-0002-3349-3994)
- Ingrid Emiliane Fonseca de Oliveira
- Marcelo Sousa-Silva
- Fred Luciano Neves Santos
- Ana Rosa Viguera
Institutions
- Universidade Federal do Rio Grande do Norte (BR)
- Fundación Biofísica Bizkaia (ES)
- Fundação Carlos Chagas (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fmicb.2026.1753585
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Federal do Rio Grande do Norte
- Fundação para a Ciência e a Tecnologia