A Conceptual Materials Engineering Framework for Multifunctional Mesostructured Inorganic Carriers: Corrected Design Principles of the Vimana System

Publication Status & Replacement Notice: This manuscript is a corrected version v2.0 replacing the earlier conceptual framework at doi:10.5281/zenodo.18844161. It preserves the original paper’s section order and design purpose, but corrects the manufacturing sequence, mechanism hierarchy, magnetic-retention language, thermal-stability claims, and regulatory interpretation. This is a self-published educational manuscript. It is not peer-reviewed, not a clinical protocol, not regulatory advice, and not evidence that the proposed carrier is safe or effective. Persistent challenges in drug stability, aqueous solubility, and pharmacokinetic variability necessitate structurally robust inorganic matrix delivery platforms. This paper defines a conceptual materials engineering framework for the Vimana system, a modular architecture integrating zirconium-modified SBA-15, exfoliated phyllosilicate nanosheets, and functional nanomaterials. By leveraging confinement-limited nucleation to maintain poorly bioavailable compounds in an amorphous or semi-amorphous state within mesoporous domains, the framework outlines design constraints for enhanced solid-state stabilization. Engineering parameters relevant to controlled release behavior, structural modularity, and theoretical external-field responsiveness are discussed at the level of materials architecture. The objective of this study is to define structural and thermodynamic design principles rather than report a validated therapeutic formulation.Additional safety note: Because intact SBA-15 or related mesoporous silica carriers may exceed the size range normally associated with rapid renal filtration, renal clearance should not be assumed. Biodistribution, degradation, renal and hepatobiliary excretion, organ-burden, and repeat-dose toxicology studies are required before any safety or clearance claim.