SSEA3 and CD105 positivity are associated with the treatment potency of human neural crest-derived nasal turbinate stem cells for Alzheimer’s disease

Our findings suggest that SSEA3/CD105 positivity is a potential marker of NTSC therapeutic efficacy for the treatment of AD. Future studies should focus on enhancing the therapeutic potential of SSEA3<sup>+</sup>/CD105<sup>+</sup> NTSCs by improving their functional efficacy and consistency, and advancing their use in clinical settings.

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Publication Details

Journal
Translational Neurodegeneration
Published
2026-03-03
DOI
https://doi.org/10.1186/s40035-026-00539-3
Primary Topic
Developmental Biology and Gene Regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

SSEA3 and CD105 positivity are associated with the treatment potency of human neural crest-derived nasal turbinate stem cells for Alzheimer’s disease

Haewon Shim, Hyun Kook Lim, Soon A Park, Seung Ho Yang et al.
Translational Neurodegeneration
Developmental Biology and Gene Regulation
article

SSEA3 and CD105 positivity are associated with the treatment potency of human neural crest-derived nasal turbinate stem cells for Alzheimer’s disease

Haewon Shim, Hyun Kook Lim, Soon A Park, Seung Ho Yang, Sin-Soo Jeun, Sunghwan Kim, Jung Yeon Lim, Jung Eun Lee, Sang In Park, Sheng-Min Wang, Minho Lee, Sung Won Kim
article en

Abstract

Our findings suggest that SSEA3/CD105 positivity is a potential marker of NTSC therapeutic efficacy for the treatment of AD. Future studies should focus on enhancing the therapeutic potential of SSEA3<sup>+</sup>/CD105<sup>+</sup> NTSCs by improving their functional efficacy and consistency, and advancing their use in clinical settings.

Translational NeurodegenerationVol. 15(1)
Dongguk University (KR), St. Mary's Hospital (US), The Catholic University of Korea St. Vincent's Hospital (KR), The Catholic University of Korea Incheon St. Mary's Hospital (KR), The Catholic University of Korea Yeouido St. Mary's Hospital (KR), St Mary's Hospital (GB), The Catholic University of Korea Seoul St. Mary's Hospital (KR), Catholic University of Korea (KR)
Good health and well-being
Openalex Percentile: Top 35%
Developmental Biology and Gene Regulation
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SSEA3 and CD105 positivity are associated with the treatment potency of human neural crest-derived nasal turbinate stem cells for Alzheimer’s disease — Haewon Shim, Hyun Kook Lim, et al. · Translational Neurodegeneration (2026) | TGRS Research Map | TGRS