A novel sex-specific role for 27-hydroxycholesterol in early-onset schizophrenia
This study represents the first evidence of sexually dimorphic oxysterol regulation in EOS and highlights 27-OHC as a sex-sensitive factor linked to clinical symptom expression, even in the absence of group-level oxysterol alterations.
Authors
- Haixia Wang (ORCID: https://orcid.org/0000-0002-0403-7797)
- Yi‐lang Tang (ORCID: https://orcid.org/0000-0003-0958-7904)
- Yuhong Li (ORCID: https://orcid.org/0000-0002-6814-8664)
- Yuanzhen Wu
- Mingxia Liu (ORCID: https://orcid.org/0000-0001-5853-904X)
- Zuoli Sun
- Rena Li
- Junjuan Yan
- Yi Zheng
Institutions
- Emory University (US)
- Capital Medical University (CN)
- Beijing Anding Hospital (CN)
- Chinese Institute for Brain Research (CN)
- Atlanta VA Medical Center (US)
Publication Details
- Journal
- Annals of General Psychiatry
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1186/s12991-026-00642-9
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00