Transcriptional Control of Hepatocellular Carcinoma Cells Aggressiveness by AAV2/8-Mediated Delivery of Human Centenarian-Associated SIRT6 N308K/A313S
These data suggest that increased intracellular stiffening mirrors increased cell motility and invasive behavior; it can be indicative of suppressed cancer development and progression by the centenarian-associated SIRT6 N308K/A313S mutant.
Authors
- Eric Leire
- Ahmed Kazaili (ORCID: https://orcid.org/0000-0002-0400-7432)
- Manlio Vinciguerra (ORCID: https://orcid.org/0000-0002-1768-3894)
- Maanya Vittal (ORCID: https://orcid.org/0000-0003-2617-8133)
- Riaz Akhtar
- Niccolò Liorni
- Tommaso Mazza
Institutions
- Libera Università Maria SS. Assunta (IT)
- University of Liverpool (GB)
- Medical University of Varna (BG)
- Agostino Gemelli University Polyclinic (IT)
- Institute of Pathology and Genetics (BE)
- Clinique Saint Jean (BE)
- Liverpool John Moores University (GB)
Publication Details
- Journal
- Cancers
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3390/cancers18050812
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00