Neddylation-Mediated hnRNPA2B1 Degradation Aggravates Retinal Endothelial Cell Dysfunction in Diabetic Retinopathy by Regulating miR-93-5p/VEGFA
HG-induced effects associated with neddylation pathways lead to hnRNPA2B1 degradation, exacerbating REC dysfunction. HnRNPA2B1, as an RNA binding protein, facilitated miR-93-5p maturation by recruiting DGCR8 within the microprocessor complex. Targeting either hnRNPA2B1 or miR-93-5p may represent a potential therapeutic strategy for preserving retinal vascular homeostasis in diabetes pending functional validation.
Authors
- Zirui Guo (ORCID: https://orcid.org/0009-0004-1817-9827)
- Jie Zhu (ORCID: https://orcid.org/0000-0002-1879-983X)
- Tianran Chen (ORCID: https://orcid.org/0009-0006-7100-7930)
- Yunfei Hou (ORCID: https://orcid.org/0000-0001-9443-4026)
- Yun-nan Zhang
- Chenxi Li (ORCID: https://orcid.org/0000-0002-7489-1075)
- Y. Cui
- Jia-Xing Zhou
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1167/iovs.67.3.5
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00