Elevated serum Interleukin-39 in Myasthenia gravis: a possible biomarker

Serum IL-39 levels are dynamically associated with disease activity states in AChR + MG, decreasing with clinical remission. Its lack of correlation with symptom severity and its likely non-specific nature suggest it may serve as a marker of general immune activation rather than a specific diagnostic or severity biomarker. Further studies are needed to validate its specificity and define its role in MG immunopathology.