Sex-specific metabolic and microbial remodeling in a rotenone-induced rat model of Parkinson’s disease following nicotine administration
Nicotine exerts neuroprotection in PD through sex-dependent modulation of multiple pathological pathways, primarily involving the gut-microbiota-metabolite axis. Females benefit from enhanced gastrointestinal protection and metabolic reprogramming, while males show preferential motor balance restoration. These findings underscore the critical importance of sex-stratified therapeutic strategies for PD.
Authors
- Pengpeng Yu (ORCID: https://orcid.org/0000-0002-7312-8940)
- Zheng Song (ORCID: https://orcid.org/0000-0001-9169-0358)
- Xiaqing Wu
- Zhen Ni (ORCID: https://orcid.org/0000-0003-0248-4523)
- Gaoge Wang
- Lei Li (ORCID: https://orcid.org/0000-0001-8723-3461)
- Hao Yu (ORCID: https://orcid.org/0000-0002-2833-6441)
- Hongwei Hou
- Qingyuan Hu
- Yibo Chen
- Huan Chen
- Qian Li
Institutions
- China Tobacco (CN)
- Beijing Academy of Social Sciences (CN)
- Tobacco Research Institute (CN)
- Beijing Academy of Science and Technology (CN)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1186/s13293-026-00865-1
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00