In-Person vs. Virtual: A Comparative Study of Teaching Methods in Nutritional Medicine

<b>Background/Objectives:</b> Nutritional medicine remains underrepresented in medical education despite its relevance across specialties. Online learning offers a resource-efficient option to address this gap, yet evidence on the effectiveness and acceptability of online learning modules (OLMs) is limited. <b>Methods:</b> In this exploratory randomized controlled single post-test trial, medical students were assigned to either an OLM or an in-person lecture (IPL) on nutritional medicine (n = 91, no a priori sample size calculation performed). After course completion, students took a knowledge test and completed a questionnaire on their learning experience. Group differences were analyzed using permutation Welch <i>t</i>-tests, Wilcoxon-Mann-Whitney tests, or Fisher's exact tests, depending on variable characteristics, with α = 0.05. <b>Results:</b> OLM students achieved significantly higher test scores than IPL students (mean difference: 2.4 points on a 0-40 scale), resulting in differences in grade classification (<i>p</i> < 0.05). OLM was further rated more favorably regarding content delivery, overall course evaluation, and exam preparation (all <i>p</i> < 0.05), while self-reported attention, concentration, and involvement did not differ between groups. Flexibility, time savings, and convenience were the most frequently reported advantages of OLM over IPL. <b>Conclusions:</b> This study suggests that OLM in nutritional medicine may be associated with higher test performance and more favorable student evaluations compared to IPL. These findings highlight the potential of online learning as a scalable, resource-efficient approach that may help address persistent gaps in nutritional medicine education. Building on this evidence, future work should examine how such modules can be optimally integrated into medical curricula to complement existing teaching structures.