Association Between Metabolic Syndrome and Psychiatric Morbidity in a Nationwide Taiwanese Population Study

<b>Background/Objectives</b>: The relationship between metabolic syndrome (MetS) and mental health disorders has gained increasing attention, yet evidence from large population-based studies remains limited. This study aimed to examine the association between MetS and psychiatric morbidity in a nationwide Taiwanese adult cohort using a cross-sectional design. <b>Methods</b>: Between 2008 and 2019, a total of 121,575 adults aged 30-70 years were recruited from 29 community health screening stations across Taiwan. Demographic characteristics, lifestyle factors, medical history, and physical measurements were collected. Participants were classified as having MetS or not according to standard criteria. Psychiatric morbidity was defined as depressive and/or anxiety burden identified by validated screening instruments (Patient Health Questionnaire-2 score ≥3 or Generalized Anxiety Disorder-2 score ≥3) or self-reported physician-diagnosed depression. Multivariable logistic regression analyses were performed to evaluate the association between MetS and psychiatric morbidity after adjustment for potential confounders. <b>Results</b>: Psychiatric morbidity was identified in 1366 of 27,349 participants with MetS (5.0%) and in 4047 of 94,226 participants without MetS (4.3%). The prevalence of psychiatric morbidity was higher among participants with MetS than those without MetS (5.0% vs. 4.3%). After multivariable adjustment, MetS was significantly associated with increased odds of psychiatric morbidity (adjusted odds ratio [aOR] 1.235; 95% confidence interval [CI] 1.152-1.325). Among individual MetS components, hypertension, increased waist circumference, and hypertriglyceridemia were independently associated with higher odds of psychiatric morbidity. <b>Conclusions</b>: MetS was associated with a modest increase in psychiatric morbidity in this large Taiwanese community cohort. Because of the cross-sectional design, causal inference is limited. Future longitudinal studies are needed to clarify the direction of association and underlying mechanisms linking metabolic and mental health conditions.