Uncovering the Untapped Potential of Furosemide in Sepsis: Real-World Evidence on Coagulopathy and Organ Outcomes

Real-world evidence suggests that furosemide use is associated with reduced sepsis-related coagulopathy and favorable organ outcomes. These findings generate a biologically plausible hypothesis consistent with Na +-K +-2Cl - cotransporter 1 (NKCC1)-related antioxidant and anti-inflammatory pathways observed in preclinical models, warranting confirmation in prospective trials.

Authors

Institutions

Publication Details

Journal
Shock
Published
2026-03-03
DOI
https://doi.org/10.1097/shk.0000000000002828
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Uncovering the Untapped Potential of Furosemide in Sepsis: Real-World Evidence on Coagulopathy and Organ Outcomes

Chun‐An Cheng, S Chen, W. U.Chien Chien, Chih-Chin Shih et al.
Shock
Sepsis Diagnosis and Treatment
article

Uncovering the Untapped Potential of Furosemide in Sepsis: Real-World Evidence on Coagulopathy and Organ Outcomes

Chun‐An Cheng, S Chen, W. U.Chien Chien, Chih-Chin Shih, Hao-Yuan Hung, Hsieh-Chou Huang, Chin-Chen Wu
article en

Abstract

Real-world evidence suggests that furosemide use is associated with reduced sepsis-related coagulopathy and favorable organ outcomes. These findings generate a biologically plausible hypothesis consistent with Na +-K +-2Cl - cotransporter 1 (NKCC1)-related antioxidant and anti-inflammatory pathways observed in preclinical models, warranting confirmation in prospective trials.

Shock
University of British Columbia (CA), University of Kang Ning (TW), Cheng Hsin General Hospital (TW), Taiwan Nurses Association (TW), Kang-Ning Junior College of Medical Care and Management (TW), National Defense Medical Center (TW)
Good health and well-being
Openalex Percentile: Top 36%
Sepsis Diagnosis and Treatment
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Uncovering the Untapped Potential of Furosemide in Sepsis: Real-World Evidence on Coagulopathy and Organ Outcomes — Chun‐An Cheng, S Chen, et al. · Shock (2026) | TGRS Research Map | TGRS