Targeted delivery of Follistatin-like 1 siRNA via biodegradable nanoparticles attenuates bleomycin-induced pulmonary fibrosis in mice
Targeted <i>Fstl1</i> inhibition using siRNA significantly mitigated pulmonary fibrosis in a murine bleomycin model. The successful application of PLGA nanomaterials for siRNA delivery underscores their potential for safe and effective <i>in vivo</i> gene silencing. These findings highlight <i>si-Fstl1</i> as a promising therapeutic candidate for IPF and support further investigation of RNA-based nanomedicine in fibrotic lung diseases.
Authors
- Huichao Chen (ORCID: https://orcid.org/0000-0002-3012-6531)
- Wen Ning
- Min Yu (ORCID: https://orcid.org/0000-0003-4371-7864)
- Maolin Yao
- Xue Li (ORCID: https://orcid.org/0000-0003-3040-7912)
- Lian Li (ORCID: https://orcid.org/0000-0002-8517-4661)
- Zhangyong Hong
- Yue Zhang
Institutions
- Tianjin University (CN)
- Kementerian Pendidikan Malaysia (MY)
- Tianjin haihe hospital (CN)
Publication Details
- Journal
- Experimental Lung Research
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1080/01902148.2026.2633914
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00