Risk-stratified surveillance after LEEP: a nomogram integrating HPV persistence, margin status, and clinical factors to predict CIN2+ recurrence
In a contemporary Chinese single-center cohort, genotype-defined persistent HPV infection and margin burden were dominant determinants of CIN2+ recurrence after LEEP, with vaccination status and NLR providing additional stratification. The resulting nomogram offers a pragmatic framework for risk-adapted surveillance, pending external multicenter validation.
Authors
- Nan Guo (ORCID: https://orcid.org/0000-0002-4667-3265)
- Xin Guo (ORCID: https://orcid.org/0000-0003-2953-7867)
- Xiaofeng Shi
- Jingfen Sun
- Qi Guo
- Haixia Shang
- Hongxin Yu
- Yue Huang
- Xiaoxue Wang
- Yaqian Feng
Institutions
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fonc.2026.1786335
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00