Single-dose Tamsulosin Induces Reversible Azoospermia and Ejaculatory Dysfunction Suggesting Potential for on-demand Male Contraception.
A single 0.8 mg dose of tamsulosin transiently suppressed seminal emission, leading to reversible azoospermia within 12 hours most recovered by 24h, and all recovered within 48h. Its predictable, reversible effect supports caution in men seeking conception and further exploration as an on-demand male contraceptive model.
Authors
- Erik Montagna (ORCID: https://orcid.org/0000-0001-6834-0261)
- Willy Baccaglini (ORCID: https://orcid.org/0000-0001-8653-3913)
- Felipe Placco Araújo Glina (ORCID: https://orcid.org/0000-0002-0420-4604)
- S. Glina
- J Candelaria
- José de Bessa
- Caio Parente Barbosa (ORCID: https://orcid.org/0000-0002-2922-0264)
- Bruna Bizio Parra de Oliveira
- Thais Ventura Feitosa
- Leonardo Seligra Lopes
Institutions
- Universidade Estadual de Feira de Santana (BR)
- Instituto Sapientia (BR)
- Faculdade de Medicina do ABC (BR)
Publication Details
- Journal
- PubMed
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1590/s1677-5538.ibju.2025.0601
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00