Assessing the usefulness of antibody index values from treponemal immunoassays to reduce confirmatory syphilis testing in the reverse algorithm
We assessed utility of antibody index values from treponemal immunoassays against confirmatory tests following reverse syphilis algorithm. We tested sera collected from a population at increased risk and established thresholds for treponemal immunoassays. High concordance with confirmatory tests was observed, indicating potential use of assay specific threshold to reduce testing.
Authors
- Kiantra Butler
- Jaeyoung Hong (ORCID: https://orcid.org/0000-0002-7962-2819)
- Mayur Shukla (ORCID: https://orcid.org/0000-0003-4378-6288)
- Phoebe Thorpe (ORCID: https://orcid.org/0000-0002-5235-0737)
- Kevin Pettus
- Arlene C. Seña
- Weiping Medlin
- Katherine Herrell
Institutions
- University of North Carolina at Chapel Hill (US)
- Centers for Disease Control and Prevention (US)
- Centers for Disease Control and Prevention (KE)
Publication Details
- Journal
- Diagnostic Microbiology and Infectious Disease
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1016/j.diagmicrobio.2026.117355
- Primary Topic
- Syphilis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00