Mesenchymal stem cell–derived exosomes derived from induced pluripotent stem cells ameliorate inflammation and promote mucosal healing via miR-34a-5p in Crohn disease
iPSC-MSC-Exos ameliorated colitis and promoted mucosal healing in a TNBS-induced CD-like model by activating Wnt/β-catenin signaling via miR-34a-5p, which targets PPP2R3A.
Authors
- Gucheng Zeng (ORCID: https://orcid.org/0000-0002-2665-2854)
- Xuanzhi Huang
- Zhirong Zeng
- Ting Feng
- Rui Feng
- Yun Qiu
- Yao He
- Minhu Chen
Institutions
- Sun Yat-sen University (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1093/ibd/izag014
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00