INPP5D/SHIP1-mediated immunometabolic remodeling of renal monocytes in idiopathic membranous nephropathy
These data delineate an INPP5D/SHIP1-centered immunometabolic program in renal monocytes as a potential regulatory factor of pathological monocyte-podocyte crosstalk in IMN. Targeting SHIP1-related PI3K/Akt pathways and monocyte immunometabolism may offer novel immunomodulatory strategies for risk stratification and disease modification in membranous nephropathy.
Authors
- Qihan Zhao (ORCID: https://orcid.org/0000-0003-4381-0591)
- B Liu
- Haoran Dai
- Hui Dai (ORCID: https://orcid.org/0000-0001-5024-559X)
- Hanxue Jiang
- Liuxiao Yang
- Wu Liu
Institutions
- Beijing University of Chinese Medicine (CN)
- Changchun University of Chinese Medicine (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fimmu.2026.1755723
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China