Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis
This is one of the most comprehensive single-cell studies of leukaemic CTCL to date. We uncover new malignant T-cell states, broaden the known repertoire of KIR expression, and propose mechanisms of immune evasion that may contribute to treatment resistance. These findings lay the groundwork for subtype-specific and microenvironment-informed therapeutic strategies in Sézary syndrome, with potential implications for guiding targeted therapy selection but require validation in larger, independent cohorts.
Authors
- Beth A. Childs (ORCID: https://orcid.org/0000-0003-3406-8890)
- Todd A. Aguilera (ORCID: https://orcid.org/0000-0002-3734-3758)
- Joseph Frank Merola (ORCID: https://orcid.org/0000-0001-6514-4353)
- Kiran A. Kumar (ORCID: https://orcid.org/0000-0003-4278-1872)
- Eslam A. Elghonaimy
- Praveen Ramakrishnan Geethakumari
- Heather W Goff
Institutions
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of the European Academy of Dermatology and Venereology
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1111/jdv.70368
- Citations
- 1
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 54.66