Quantitative evaluation of T-cell repertoire restoration following hematopoietic stem cell transplantation in patients with and without graft versus host disease
The dynamic changes and shared signatures within the TCR repertoire are closely associated with the development and resolution of aGVHD. These findings indicate that monitoring the TCR repertoire could serve as a valuable tool for predicting the onset of aGVHD. This approach holds promise for facilitating more personalized diagnostic and treatment strategies for aGVHD, and potentially for other T-cell-mediated pathologies.
Authors
- X. G. Zhang
- Xuefeng He
- XIAOHUI HU
- Yuxuan Wang (ORCID: https://orcid.org/0000-0002-1649-6974)
- Xiaopeng Tian
- Mingyuan Wang (ORCID: https://orcid.org/0000-0003-2519-1176)
- Huiying Qiu (ORCID: https://orcid.org/0000-0002-1014-2403)
- Longhai Tang
- XiangJun Ji
- Suning Chen
- Shengli XUE
- F Chen
- Wenbo Wang
- Xiaowen Tang
- Depei Wu
- Weiyang Li
- Miao Miao
- Pengyi Song
- Xiao Ma
- Jun Wang
Institutions
- Soochow University (CN)
- National Clinical Research (US)
- Shanghai Tenth People's Hospital (CN)
- Wuhan Blood Center (CN)
- Biopharma Technology (United Kingdom) (GB)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fimmu.2026.1778172
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00