Growth differentiation factor-15 as a clinical biomarker of frailty, sarcopenia and functional decline: A systematic literature review
These findings support the integration of GDF-15 into precision geriatric care, though further longitudinal and interventional studies, including those evaluating the incremental value of adding GDF-15 to existing screening tools for frailty, sarcopenia, and functional status, are required to establish its clinical utility.
Authors
- Chun En Yau (ORCID: https://orcid.org/0000-0002-5844-8962)
- Amanda Weiling Tan
- Chen Ee Low (ORCID: https://orcid.org/0000-0002-8652-0984)
- Reshma Aziz Merchant (ORCID: https://orcid.org/0000-0002-9032-0184)
- Ainsley Ryan Yan Bin Lee (ORCID: https://orcid.org/0000-0002-5896-2929)
- Anjin Hong
- Vidhya Nachammai
Institutions
- Ministry of Health (SG)
- The University of Queensland (AU)
- National University of Singapore (SG)
- National University Hospital (SG)
Publication Details
- Journal
- Ageing Research Reviews
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1016/j.arr.2026.103085
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00