Synergistic elastase and papain injury drives abdominal aortic aneurysm formation and rupture in mice
This murine model, using a synergistic combination of pancreatic elastase and papain, effectively replicates AAA pathophysiology and is ideal for investigating underlying mechanisms and potential therapeutic interventions.
Authors
- Batool Arif (ORCID: https://orcid.org/0009-0006-3610-0865)
- Ibrahim Kuziez
- Mohamed A. Zayed
- Mohamed S. Zaghloul
- Ryan Wahidi
- Santiago Elizondo-Benedetto
Institutions
- Washington University in St. Louis (US)
- VA St. Louis Health Care System (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1038/s43856-026-01485-x
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00