Omadacycline Monotherapy in Nontuberculous Mycobacterial Pulmonary Disease Caused by <i>Mycobacterium abscessus</i> : Results From a Phase 2, Double-blind, Randomized, Placebo-controlled Study
Results consistently favored omadacycline monotherapy over placebo across several endpoints in NTM-PD caused by M. abscessus. Omadacycline was well tolerated; nausea was the most frequent TEAE. Further investigations are warranted.
Authors
- Patrick A. Flume (ORCID: https://orcid.org/0000-0002-1560-6879)
- Anita F Das
- Alissa Sirbu
- Chakrapol Sriaroon
- Daniel Deck
- Surya Chitra (ORCID: https://orcid.org/0000-0002-5682-9200)
- Diane Anastasiou
- Stephen Villano
- Amy Manley
- Reeti Khare
- Kevin L Winthrop
- Alisa W Serio
Institutions
- Portland State University (US)
- Medical University of South Carolina (US)
- Oregon Health & Science University (US)
- University of South Florida (US)
- National Jewish Health (US)
- Paratek Pharmaceuticals (United States) (US)
- West County Health Centers (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1093/cid/ciag062
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00