Risk of Metachronous Colorectal Cancer After Segmental or Extended Resection in Patients with Lynch Syndrome
For CRC patients with variants in high-risk LS genes, extended resection can significantly reduce the risk of metachronous CRC but does not lengthen overall survival. Segmental resection with close endoscopic surveillance can be a reasonable alternative, given the opportunity for repeat surgery and/or immune checkpoint blockade.
Authors
- M. Gönen
- Thikhamporn Tawantanakorn (ORCID: https://orcid.org/0000-0001-8468-4347)
- Z. Stadler
- Jinru Shia (ORCID: https://orcid.org/0000-0002-4351-2511)
- Matthew B. Hill
- Martin R Weiser
- Alicia Latham
- Mohammad A Abbass
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Journal of the American College of Surgeons
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1097/xcs.0000000000001892
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00