Long term safety and efficacy of a functionalized nanogel with endothelin-1 and bradykinin receptor antagonist peptides for treatment of osteoarthritis of the metacarpophalangeal and distal interphalangeal joints in horses: a descriptive clinical pil

Intra-articular administration of a peptide-functionalized nanogel was feasible and well tolerated in sport horses with naturally occurring OA and was associated with partial but prolonged clinical improvement. Although only half of the horses achieved full return to pre-lameness performance, most showed sustained clinical benefit without additional treatment over one year. These findings support further investigation of this drug delivery system in larger, randomized controlled trials to better define its therapeutic efficacy and optimal indications.

Authors

Institutions

Publication Details

Journal
BMC Veterinary Research
Published
2026-03-03
DOI
https://doi.org/10.1186/s12917-026-05368-0
Primary Topic
Osteoarthritis Treatment and Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Long term safety and efficacy of a functionalized nanogel with endothelin-1 and bradykinin receptor antagonist peptides for treatment of osteoarthritis of the metacarpophalangeal and distal interphalangeal joints in horses: a descriptive clinical pil

Aurélie Cullier, Seng Manivong, S Jacquet, Amélie Tallaj et al.
BMC Veterinary Research
Osteoarthritis Treatment and Mechanisms
article

Long term safety and efficacy of a functionalized nanogel with endothelin-1 and bradykinin receptor antagonist peptides for treatment of osteoarthritis of the metacarpophalangeal and distal interphalangeal joints in horses: a descriptive clinical pil

Aurélie Cullier, Seng Manivong, S Jacquet, Amélie Tallaj, Florence Legendre, Florina Moldovan, Pierré Sirois, Gaelle V Roullin, Magali Demoor, Philippe Galéra, Antoinette Terlinden, Xavier Banquy, Virginie Coudry, Fabrice Audigié, Araceli Ac Garcia, Lélia Bertoni
article en

Abstract

Intra-articular administration of a peptide-functionalized nanogel was feasible and well tolerated in sport horses with naturally occurring OA and was associated with partial but prolonged clinical improvement. Although only half of the horses achieved full return to pre-lameness performance, most showed sustained clinical benefit without additional treatment over one year. These findings support further investigation of this drug delivery system in larger, randomized controlled trials to better define its therapeutic efficacy and optimal indications.

BMC Veterinary Research
École Nationale Vétérinaire d'Alfort (FR), Centre Hospitalier Universitaire Sainte-Justine (CA), Normandie Université (FR), Université Laval (CA), Ho Chi Minh City University of Technology (VN), Université de Montréal (CA)
Good health and well-being
Openalex Percentile: Top 35%
Osteoarthritis Treatment and Mechanisms
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Long term safety and efficacy of a functionalized nanogel with endothelin-1 and bradykinin receptor antagonist peptides for treatment of osteoarthritis of the metacarpophalangeal and distal interphalangeal joints in horses: a descriptive clinical pil — Aurélie Cullier, Seng Manivong, et al. · BMC Veterinary Research (2026) | TGRS Research Map | TGRS