Sex-associated transcriptional changes to synovial macrophages in the aging joint
In summary, we report on both conserved age-related changes and those that differed between males and females. Our results provide insights on how macrophage heterogeneity changes with age in a sex-dimorphic manner and lays the foundation for research into their role in age-associated diseases, such as arthritis.
Authors
- Moriz Mayer (ORCID: https://orcid.org/0000-0003-3432-4348)
- M. E. Bowdish Dawn
- Carla M. Cuda (ORCID: https://orcid.org/0000-0002-2022-8171)
- Deborah R. Winter (ORCID: https://orcid.org/0000-0003-1806-673X)
- Cally Mills (ORCID: https://orcid.org/0000-0002-7743-8815)
- Tyler Therron
- Yidan Wang (ORCID: https://orcid.org/0000-0003-2490-8999)
- Samuel Hamilton
- Samuel D. Dowling
- Matthew Dapas
- Erica N. DeJong
Institutions
- Northwestern University (US)
- Center for Human Genetics (US)
- McMaster University (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fimmu.2026.1724385
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Northwestern University
- National Institutes of Health
- Feinberg School of Medicine
- Robert H. Lurie Comprehensive Cancer Center
- Quest High Performance Computing
- National Cancer Institute