Hedyotis diffusa Willd. extract alleviates CCl4-induced liver fibrosis via modulation of the gut microbiota and FXR/SHP/CYP7A1-mediated bile acid metabolism
HDW exerts significant antifibrotic effects in CCl<sub>4</sub>-induced liver fibrosis via a gut microbiota-dependent mechanism involving the restoration of BA metabolism and the activation of the hepatic FXR/SHP/CYP7A1 axis. Given its ability to modulate gut microbial ecology, BA homeostasis and intestinal barrier integrity simultaneously, HDW is a promising therapeutic candidate for targeting the gut microbiota in the treatment of liver fibrosis.
Authors
- Cheng Wang (ORCID: https://orcid.org/0000-0002-1834-2119)
- Min Luo (ORCID: https://orcid.org/0000-0003-1028-461X)
- Lingli Zheng
- Qixiang Chen
- Min Dai
- Ting Jiang
Institutions
- Chengdu Medical College (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1016/j.jep.2026.121450
- Citations
- 1
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 23.38