Characterization of Kidney and Liver Cystic Phenotype Associated with GANAB Using Advanced Imaging Biomarkers
Quantitative imaging reveals a phenotypic spectrum in ADPKD-GANAB, ranging from liver-predominant cystic disease with minimal kidney involvement to a phenotype with higher kidney cyst burden and faster eGFR decline. Establishing robust genotype-phenotype relationships in this rare disease will require larger, aggregated cohorts with standardized imaging and systemic extrarenal screening.
Authors
- Z Zoghby
- Timothy L. Kline (ORCID: https://orcid.org/0000-0002-7917-9853)
- Mikhail D. Antoun
- Christian Hanna (ORCID: https://orcid.org/0000-0002-9956-8696)
- Stefan Paul (ORCID: https://orcid.org/0000-0003-2344-4539)
- Ahmad Ghanem (ORCID: https://orcid.org/0000-0002-4925-2677)
- Fadi George Munairdjy Debeh (ORCID: https://orcid.org/0009-0001-0581-1211)
- Besher Shami
- R. Schauer
- Peter Harris
- Bassel Alkhatib
- Hana Yang
- Neera K. Dahl
- Marie C Hogan
- Dana Hanna
- Adriana Gregory
- Abdul Hamid Borghol
- Nay Nader
- Vineetha Rangarajan
- Fouad T. Chebib
Publication Details
- Journal
- The Nephron journals/Nephron journals
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1159/000551274
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00