Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics

Stromal and perivascular cells are the main cell types that are sensitive to ovarian cryopreservation. The FOS/AP-1 pathway is markedly activated after, suggesting the exacerbation of metabolic impairment. In oocytes within the ovarian cortex, the cell cycle and meiosis-related physiological processes were the primary processes affected.

Authors

Yanquan Li
Fanghao Guo (ORCID: https://orcid.org/0009-0009-0795-8362)
Meiling Zhang (ORCID: https://orcid.org/0000-0003-1256-5511)
Di Sun (ORCID: https://orcid.org/0000-0002-6010-7331)
Baicai Yang
Songmao Li
Li Zhang
Mengxi Guo
Yongjian Ma
Wen Li
Haixia Ding
Qing Zhang
Rui Qiao

Institutions

Shanghai University (CN)
International Peace Maternity & Child Health Hospital (CN)
Institute of Refrigeration (GB)

Publication Details

Journal: BMC Medicine
Published: 2026-03-03
DOI: https://doi.org/10.1186/s12916-026-04757-4
Primary Topic: Reproductive Biology and Fertility
Type: article
Field-Weighted Citation Impact: 0.00

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article

Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics

Yanquan Li, Fanghao Guo, Meiling Zhang, Di Sun et al.

Mar 3, 2026

BMC Medicine

Reproductive Biology and Fertility

article

Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics

Yanquan Li, Fanghao Guo, Meiling Zhang, Di Sun, Baicai Yang, Songmao Li, Li Zhang, Mengxi Guo, Yongjian Ma, Wen Li, Haixia Ding, Qing Zhang, Rui Qiao

March 3, 2026article en

Abstract

Stromal and perivascular cells are the main cell types that are sensitive to ovarian cryopreservation. The FOS/AP-1 pathway is markedly activated after, suggesting the exacerbation of metabolic impairment. In oocytes within the ovarian cortex, the cell cycle and meiosis-related physiological processes were the primary processes affected.

BMC Medicine

Shanghai University (CN), International Peace Maternity & Child Health Hospital (CN), Institute of Refrigeration (GB)

Openalex Percentile: Top 40%

Reproductive Biology and Fertility

DOI Open Access PDF OpenAlex

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Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics — Yanquan Li, Fanghao Guo, et al. · BMC Medicine (2026) | TGRS Research Map | TGRS