Breakthrough Invasive Fungal Infections in Pediatric Acute Myeloid and Lymphoblastic Leukemia Receiving Mold-active Prophylaxis

Despite mold-active antifungal prophylaxis, nearly one-third of pediatric leukemia patients developed IFIs, with high mortality in probable and proven cases. The predominance of breakthrough mold infections underscores the limitations of current prophylactic strategies. Optimized prophylaxis, therapeutic drug monitoring and early diagnostic approaches are urgently needed to reduce the burden of IFIs in this high-risk population.

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Publication Details

Journal
The Pediatric Infectious Disease Journal
Published
2026-03-03
DOI
https://doi.org/10.1097/inf.0000000000005196
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
0.00
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article

Breakthrough Invasive Fungal Infections in Pediatric Acute Myeloid and Lymphoblastic Leukemia Receiving Mold-active Prophylaxis

turan bayhan, F. Nur Ünal, Hatice Kübra Konca, Özlem Arman et al.
The Pediatric Infectious Disease Journal
Antifungal resistance and susceptibility
article

Breakthrough Invasive Fungal Infections in Pediatric Acute Myeloid and Lymphoblastic Leukemia Receiving Mold-active Prophylaxis

turan bayhan, F. Nur Ünal, Hatice Kübra Konca, Özlem Arman, Seval Çevik Özen, Aysun Yahşi, Belgin Gülhan, Nese Yarali, TUĞBA ERAT, GÜLSÜM İCLAL BAYHAN, Namik Yasar Ozbek
article en

Abstract

Despite mold-active antifungal prophylaxis, nearly one-third of pediatric leukemia patients developed IFIs, with high mortality in probable and proven cases. The predominance of breakthrough mold infections underscores the limitations of current prophylactic strategies. Optimized prophylaxis, therapeutic drug monitoring and early diagnostic approaches are urgently needed to reduce the burden of IFIs in this high-risk population.

The Pediatric Infectious Disease Journal
Ministry of Health (TR), Bilkent University (TR), University of Health Science (KH), Sağlık Bilimleri Üniversitesi (TR), Ankara Yıldırım Beyazıt University (TR)
Good health and well-being
Openalex Percentile: Top 37%
Antifungal resistance and susceptibility
DOISourceOpenAlex
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Breakthrough Invasive Fungal Infections in Pediatric Acute Myeloid and Lymphoblastic Leukemia Receiving Mold-active Prophylaxis — turan bayhan, F. Nur Ünal, et al. · The Pediatric Infectious Disease Journal (2026) | TGRS Research Map | TGRS