Preliminary lipidomics and transcriptomics reveals stage-specific dynamic metabolic patterns from menopause transition to postmenopause

This preliminary study indicates that menopausal stages are associated with significant stage-specific differences in lipid metabolism and gene expression, with the menopause transition identified as a critical phase of lipid metabolic reorganization. Certain lipids and genes may serve as potential biomarkers for menopause-associated metabolic differences. These findings provide important insights for early warning and intervention strategies targeting menopause-related health issues.