Associations of anticholinergic burden of medication with cognitive decline and longitudinal brain atrophy in the Alzheimer’s disease spectrum
In the presence of prodromal or manifest AD, in a memory clinic-based cohort anticholinergic burden had only a modest effect on cognitive decline and no effect on atrophy in brain regions that are related to the cholinergic system.
Authors
- Britta Haenisch (ORCID: https://orcid.org/0000-0002-4828-6058)
- Alice Grazia (ORCID: https://orcid.org/0000-0001-8861-3183)
- Jonas Peltner (ORCID: https://orcid.org/0000-0002-1682-7913)
- Emrah Duezel
- Michael Wagner
- Oliver Peters
- Ingo Kilimann
- Claudia Bartels
- Anja Schneider
- Frank Jessen
- Jens Wiltfang
- Björn Hendrik Schott
- Josef Priller
- Christoph Laske
- Stefan Teipel
- Annika Spottke
- Renat Yakupov
- Robert Perneczky
- Katharina Buerger
Institutions
- Federal Institute for Drugs and Medical Devices (DE)
- University of Bonn (DE)
- University of Cologne (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- University Medical Center (US)
- LMU Klinikum (DE)
- Hertie Institute for Clinical Brain Research (DE)
- University of Rostock (DE)
- University of Göttingen (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fnagi.2026.1751326
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00