Associations of childhood trauma with clinical features and inflammatory cytokines in adolescents with first-episode and recurrent major depressive disorder
Childhood trauma is common in adolescents with MDD and associated with more severity of depression, suicidal ideation, and alexithymia. Its link to inflammatory cytokines is exclusively observed in first-episode patients, suggesting trauma-related immune activation may be particularly important in initial onset.
Authors
- Daming Mo
- Lewei Liu
- Ruitong Li (ORCID: https://orcid.org/0000-0002-9227-7191)
- Lei Xia (ORCID: https://orcid.org/0009-0000-2018-5012)
- Mingru Hao
- Xi Zhang
- Huanzhong Liu
- Yun Zhang
- Haojie Fan
- Feng Geng
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Fourth Affiliated Hospital of Anhui Medical University (CN)
- Hologic (Germany) (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3389/fimmu.2026.1787595
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00