Class switching toward IgG4 six months after primary mRNA-based COVID-19 vaccination in kidney patients
Approximately half of KTRs lacked detectable S-binding B cells after two mRNA-1273 doses, despite antibody formation. Among responders, S-binding B cells persisted up to 6 months after vaccination with a relative shift toward IgG4, a pattern also observed in dialysis patients, CKD patients and controls. The clinical significance of this subclass skewing requires confirmation in larger cohorts with functional antibody readouts.
Authors
- Luuk B. Hilbrands (ORCID: https://orcid.org/0000-0002-4935-9765)
- Mathieu Claireaux (ORCID: https://orcid.org/0000-0003-1890-9493)
- Nelly van der Bom-Baylon
- Sophie Frölke
- Kenney Gino Amirkhan
- Suzanne E. Geerlings
- Jan-Stephan F. Sanders
- Rory D. de Vries
- Michiel C. van Aalderen
- Ester B. M. Remmerswaal
- Marit van Gils
- Dimitri A. Diavatopoulos
- Frederike J. Bemelman
- A. Lianne Messchendorp
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- University of Groningen (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Amsterdam Neuroscience (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- GGD Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- Institute of Infection and Immunity (CA)
- University of Amsterdam (NL)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1371/journal.pone.0336320
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amsterdam University Medical Centers
- ZonMw
- Universiteit van Amsterdam
- Institute of Infection and Immunity