Shared genetic structure between COVID-19 and migraine: insights from large-scale genome-wide cross-trait analysis
COVID-19 phenotypes and migraine shared genetic structures, though no causality was detected. Pleiotropic genes play key roles in the mTOR and beta catenin pathways, with tissue enrichment in lung, cerebral cortex, and specific immune cells, suggesting a potential mechanism for shared susceptibility.
Authors
- Jinniu Guo
- Jinzhao Jiang
- Yu Long
- Ruohan Sun
- Jinfeng Liu
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Virus Research
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1016/j.virusres.2026.199708
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00