The related EIF4G3 and EIF4G4 initiation factors from Leishmania: dissimilar modes of action during translation revealed by a comparative proteomic approach

Overall, new and more defined binding partners were observed for EIF4G3, with EIF4G4 having an increased coprecipitation with other translation initiation factors. Newly identified partners, for both eIF4Gs, might facilitate specific mRNA recognition or function regulating translation during growth. Further studies on some of those might reveal unique and conserved aspects of the Leishmania translation and might help define targets for novel translation inhibitors.