Prognostic impact of high-risk plaque morphology and impaired physiology in untreated non-culprit coronary lesions: a systematic review and meta-analysis

High-risk plaque morphology and impaired physiology were independently associated with adverse outcomes in untreated NCLs, while their coexistence identified lesions at highest risk. An integrated morpho-functional assessment may improve risk stratification in multivessel coronary artery disease.

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Publication Details

Journal
IJC Heart & Vasculature
Published
2026-03-03
DOI
https://doi.org/10.1016/j.ijcha.2026.101895
Primary Topic
Coronary Interventions and Diagnostics
Type
article
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article

Prognostic impact of high-risk plaque morphology and impaired physiology in untreated non-culprit coronary lesions: a systematic review and meta-analysis

Vincenzo De Sio, Flavio Giuseppe Biccirè, Arturo Cesaro, Vincenzo Acerbo et al.
IJC Heart & Vasculature
Coronary Interventions and Diagnostics
article

Prognostic impact of high-risk plaque morphology and impaired physiology in untreated non-culprit coronary lesions: a systematic review and meta-analysis

Vincenzo De Sio, Flavio Giuseppe Biccirè, Arturo Cesaro, Vincenzo Acerbo, Maria Grazia Monaco, Paolo Calabrò, Felice Gragnano, Francesco Prati, Antonio Capolongo, Francesco Pelliccia, Dobromir Dobrev
article en

Abstract

High-risk plaque morphology and impaired physiology were independently associated with adverse outcomes in untreated NCLs, while their coexistence identified lesions at highest risk. An integrated morpho-functional assessment may improve risk stratification in multivessel coronary artery disease.

IJC Heart & VasculatureVol. 63
Baylor College of Medicine (US), University of Campania "Luigi Vanvitelli" (IT), Azienda Ospedaliera San Giovanni Addolorata (IT), Montreal Heart Institute (CA), Ospedale Sant'Anna (IT), West German Heart and Vascular Center Essen (DE), Université de Montréal (CA), Sapienza University of Rome (IT)
Openalex Percentile: Top 35%
Coronary Interventions and Diagnostics
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Prognostic impact of high-risk plaque morphology and impaired physiology in untreated non-culprit coronary lesions: a systematic review and meta-analysis — Vincenzo De Sio, Flavio Giuseppe Biccirè, et al. · IJC Heart & Vasculature (2026) | TGRS Research Map | TGRS