Mesencephalic astrocyte-derived neurotrophic factor attenuates sepsis-associated encephalopathy by inhibiting oxidative stress and pyroptosis
The results of the present study indicate that MANF alleviates SAE, likely by inhibiting ROS-GSDMD-dependent microglial pyroptosis.
Authors
- Qiying Shen (ORCID: https://orcid.org/0000-0002-6415-3458)
- Jingwen Ning
- Yu-jun Shen
- En-ba Zhuo
- Li-Xia Wang
- Chen Wang
- Jie Gao
- Jing Liu
- Yan-Chao Tang
- Lei-Ying Zhou
- Yan-Nan Zhou
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1016/j.brainresbull.2026.111809
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00