Predictive value of the 68Ga-PSMA-11 PET/CT PRIMARY score for pathological upgrading in patients with ISUP Grade 1 prostate cancer and PSA < 20 ng/mL undergoing radical prostatectomy
"The <sup>68</sup>Ga-PSMA-11 PET/CT PRIMARY score was strongly associated with pathological upgrading in this surgically treated cohort of biopsy-confirmed ISUP GG1 patients with PSA < 20 ng/mL undergoing radical prostatectomy. Incorporating PSMA-based intraprostatic pattern analysis could improve the accuracy of preoperative grading, potentially supporting consideration of surgical management rather than definitive radiotherapy when determining the optimal treatment strategy. Prospective multicenter validation is warranted before broader clinical implementation.
Authors
- Burcin Karasah Erkek (ORCID: https://orcid.org/0000-0002-4972-0936)
- Hatice Sariyildiz Gumusgoz
- Esra Çiftçi (ORCID: https://orcid.org/0000-0001-6106-7733)
- Burak Akovali
Institutions
- Sakarya University (TR)
- Çanakkale Onsekiz Mart Üniversitesi (TR)
- Ministry of Health (TR)
- Sakarya Eğitim ve Araştırma Hastanesi (TR)
- Education Training And Research (US)
Publication Details
- Journal
- Annals of Nuclear Medicine
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1007/s12149-026-02179-z
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00